@Article{Raszeja-Wyszomirska2013,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="8",
number="3",
year="2013",
title="Secretory phospholipase A2 activity is linked to hypercholesterolemia and gender in non-alcoholic fatty liver disease individuals",
abstract=" Introduction:  Non-alcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome, which is a constellation of insulin resistance, central obesity, dyslipidemia and inflammation. During the inflammatory process polyunsaturated fatty acids are converted into proinflammatory hydroperoxides by the action of lipoxygenases, e.g. secretory phospholipase A 2  (sPLA 2 ).    Aim : The role of sPLA 2  during progression of inflammation in NAFLD is practically unknown; therefore the aim of the study was to investigate sPLA 2  activity in NAFLD patients.    Material and methods : Ninety-two patients with NAFLD and 20 healthy individuals were enrolled in the study. sPLA 2  activity in plasma was evaluated by the ELISA method.    Results:  There were no differences between NAFLD and healthy individuals in sPLA 2  activity but among NAFLD individuals high sPLA 2  activity was linked to male gender and high concentration of plasma cholesterol (hypercholesterolemia). A trend for a correlation between 8-epi-PGF 2α  III concentration in plasma and sPLA 2  activity was observed.   Conclusions:  sPLA 2  is one of the main factors associated with progression of inflammatory diseases including NAFLD. A positive correlation between total cholesterol in plasma and activity of sPLA 2  in men may contribute to the pathogenesis of NAFLD as well as progression to steatohepatitis according to novel “one hit” theory.",
author="Raszeja-Wyszomirska, Joanna
and Safranow, Krzysztof
and Szynkowska, Agnieszka
and Stachowska, Ewa",
pages="172--175",
doi="10.5114/pg.2013.36330",
url="http://dx.doi.org/10.5114/pg.2013.36330"
}