@Article{Rychlik-Sych2013,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="30",
number="4",
year="2013",
title="Original paperGenetic polymorphisms of CYP2D6 oxidation in patients with autoimmune bullous diseases",
abstract=" Introduction:  Bullous skin diseases, which include, among others pemphigoid, pemphigus, and dermatitis herpetiformis are classified as severe autoimmune dermatoses. It has been shown that a pattern of xenobiotic metabolism may play a role in the pathogenesis of autoimmune diseases.    Aim:  To estimate whether the CYP2D6 genotype may be considered a predisposing factor in autoimmune bullous diseases induction.    Material and methods : The study included 72 patients with autoimmune bullous diseases: 37 with pemphigoid,   21 with pemphigus, and 14 with dermatitis herpetiformis (DH). The CYP2D6 genotypes were analyzed by the polymerase chain reaction fragment length polymorphism (PCR-RFLP) method.    Results:  Relative risk of DH development for particular genotype carriers expressed by odds ratio (OR) was statistically significantly higher for subjects with CYP2D6*1/CYP2D6*4 (OR = 4.2; p = 0.0104) and 2-fold higher for subjects with CYP2D6*4 (OR = 2.3; p = 0.0351).   Conclusions : The results of the present study show that the CYP2D6 oxidation polymorphism cannot be considered a risk factor for development of pemphigoid and pemphigus, however it might have an impact on dermatitis herpetiformis.",
author="Rychlik-Sych, Mariola
and Baranska, Małgorzata
and Waszczykowska, Elzbieta
and Torzecka, Jolanta Dorota
and Zebrowska, Agnieszka
and Skretkowicz, Jadwiga",
pages="211--217",
doi="10.5114/pdia.2013.37030",
url="http://dx.doi.org/10.5114/pdia.2013.37030"
}