@Article{Siniewicz-Luzeńczyk2013,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="30",
number="5",
year="2013",
title="Original papersCorrelation between serum interleukin 31 level and the severity of disease in children with atopic dermatitis",
abstract=" Introduction:  Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD.    Aim:  To assess the correlation of serum IL-31 level and the disease severity in children with AD.   Material and methods : Twenty-five children (16 girls and 9 boys) with AD aged from 4 months to 17 years (mean age:   4.2 years) were enrolled in the study. Disease severity in children with AD was assessed using the SCORAD (Severity   SCORing of Atopic Dermatitis) index. Serum IL-31 levels were measured using ELISA with standard kits from EIAab R\&D Systems.    Results:  Serum IL-31 level was significantly higher in AD children than in healthy children. There was no statistic correlation between serum IL-31 level and the disease severity or itch intensity.   Conclusions : The disease severity and itch intensity do not correlate with serum IL-31 level in children with atopic dermatitis.",
author="Siniewicz-Luzeńczyk, Katarzyna
and Stańczyk-Przyłuska, Anna
and Zeman, Krzysztof",
pages="282--285",
doi="10.5114/pdia.2013.38356",
url="http://dx.doi.org/10.5114/pdia.2013.38356"
}