@Article{Czopek2013,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="17",
number="5",
year="2013",
title="HER-3 expression in HER-2-amplified breast carcinoma",
abstract=" Aim of the study : To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC).   Material and methods : In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues.   Results : Higher HER-3 status if estimated by IHC correlated significantly with older age of the patients. HER-3 expression did not correlate with estrogen or progesterone receptor status, pT or pN. There was also no significant difference in disease-free or overall survival (DFS and OS) between groups with different HER-3 expression, although some tendencies were seen as HER-3 expression in over 50% of cells was a factor of worse 5- and 10-year survival.   Conclusions : Further studies should be performed on a larger group of patients to confirm the prognostic role of HER-3 status determined by IHC in BC.",
author="Czopek, Jacek
and Pawlęga, Janusz
and Fijorek, Kamil
and Püsküllüoğlu, Mirosława
and Różanowski, Paweł
and Okoń, Krzysztof",
pages="446--449",
doi="10.5114/wo.2013.38564",
url="http://dx.doi.org/10.5114/wo.2013.38564"
}