@Article{Rybakowski2013,
journal="Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology",
issn="1896-6764",
volume="8",
number="3",
year="2013",
title="Original articlePersonality traits measured with TEMPS-A and O-LIFE and polymorphism of BDNF, COMT and serotonin transporter genes in bipolar affective illness",
abstract=" Aim of the study : This study assesses an association between functional polymorphisms of the brain-derived neurotrophic factor ( BDNF ) gene, catechol-O-methyltransferase ( COMT ) gene and serotonin transporter gene and personality dimensions measured by the Temperament Scale of Memphis, Pisa, Paris and San Diego – Autoquestionnaire (TEMPS-A) and the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) in patients with bipolar affective illness.   Material and methods : The study was performed on 70 patients with bipolar affective illness (21 men, 49 women) aged 59 ±12 years, from the outpatient clinic, Department of Adult Psychiatry, Poznan University of Medical Sciences. The TEMPS-A was applied, measuring depressive, hyperthymic, cyclothymic, irritable and anxious temperament as well as the O-LIFE, measuring schizotypy dimensions: unusual experiences, cognitive disorganization, introversion and anhedonia and impulsive nonconformity. Genotyping of Val66Met polymorphism of the  BDNF  gene, Val108Met polymorphism of the  COMT  gene and 5-HTLPR s/l polymorphism of the serotonin transporter gene was performed.   Results : Carriers of the Met allele of Val66Met  BDNF  gene polymorphism showed significantly higher irritability dimension on TEMPS-A. Among carriers of the Met allele of Val108Met  COMT  gene polymorphism, significantly higher cognitive disorganization and introvertive anhedonia on O-LIFE were observed. Finally, patients with s/s genotype of 5-HTLPR polymorphism had a higher cyclothymia dimension at the level of a statistical trend (p = 0.06).   Conclusions:  The association between  BDNF  gene polymorphism and irritability in the TEMPS-A has not been previously reported. A connection between the  COMT  gene and features of schizotypy as well as between the serotonin transporter gene and cyclothymia is discussed in the context of results of other researchers.",
author="Rybakowski, Janusz
and Dmitrzak-Węglarz, Monika
and Dembińska-Krajewska, Daria
and Hauser, Joanna",
pages="94--100",
url="https://www.termedia.pl/Original-article-Personality-traits-measured-with-TEMPS-A-and-O-LIFE-and-polymorphism-of-BDNF-COMT-and-serotonin-transporter-genes-in-bipolar-affective-illness,46,22202,1,1.html"
}