@Article{Maciejewska-Radomska2015,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="32",
number="6",
year="2015",
title="Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland",
abstract=" Introduction : The association of guttate psoriasis with a streptococcal throat infection and HLA- Cw*06  allele is well established in different populations. Nevertheless, only few studies on this form of disease have been performed in the Polish population.    Aim:   To analyze the frequencies of streptococcal-induced guttate psoriasis and HLA- Cw*06  allele in 70 patients with guttate psoriasis originating from northern Poland.    Material and methods:  Seventy patients with guttate psoriasis and 24 healthy volunteers were enrolled into the study. Both groups were sex- and age-matched. The evidence of streptococcal infection was based on the positive throat swabs and/or elevated ASO titers. The modified method, including PCR-SSP and PCR-RFLP, was applied to HLA- Cw*06  genotyping.    Results:   HLA- Cw*06  allele was confirmed in 49 (70%) out of 70 patients, which is significantly higher than in the control population (30%) (p = 0.001). Evidence for streptococcal infection was found in 34 (48.5%) subjects with psoriasis. Twenty-seven of them (79%) carried HLA- Cw*06  allele. In 36 individuals in whom no evidence of streptococcal infection was found, 14 (39%) did not carry HLA- Cw*06  allele.   Conclusions : Our data confirm that HLA- Cw*06  is a major, but not imperative, genetic determinant for guttate psoriasis.",
author="Maciejewska-Radomska, Agata
and Szczerkowska-Dobosz, Aneta
and Rębała, Krzysztof
and Wysocka, Joanna
and Roszkiewicz, Jadwiga
and Szczerkowska, Zofia
and Placek, Waldemar",
pages="455--458",
doi="10.5114/pdia.2014.40982",
url="http://dx.doi.org/10.5114/pdia.2014.40982"
}