@Article{Gomez-Iturriaga2014,
journal="Journal of Contemporary Brachytherapy",
issn="1689-832X",
volume="6",
number="2",
year="2014",
title="Original paperImpact of intraoperative MRI/TRUS fusion on dosimetric parameters in cT3a prostate cancer patients treated with high-dose-rate real-time brachytherapy",
abstract=" Purpose:  The purpose of this study was to evaluate the impact of intraoperative MRI/TRUS fusion procedure in cT3a prostate cancer patients treated with high-dose-rate (HDR) real-time brachytherapy.    Material and methods : Prostate gland, dominant intraprostatic lesions (DILs), and extracapsular extension (ECE) were delineated in the pre-brachytherapy magnetic resonance images (MRI) of 9 consecutive patients. The pre-implant P-CTV US  (prostate clinical target volume) was defined as the prostate seen in the transrectal ultrasound (TRUS) images. The CTV MR  includedthe prostate with the ECE image (ECE-CTV) as defined on the MRI. Two virtual treatment plans were performed based on the MRI/TRUS fusion images, the first one prescribing 100% of the dose to the P-PTV US , and the second prescribing to the PTV MR . The implant parameters and dose-volume histogram (DVH) related parameters of the prostate, OARs, and ECE were compared between both plans.    Results : Mean radial distance of ECE was 3.6 mm (SD: 1.1). No significant differences were found between prostate V 100 , V 150 , V 200 , and OARs DVH-related parameters between the plans. Mean values of ECE V 100 , V 150 , and V 200  were 85.9 % (SD: 15.1), 18.2 % (SD: 17.3), and 5.85 % (SD: 7) when the doses were prescribed to the PTV US , whereas ECE V 100 , V 150 , and V 200  were 99.3 % (SD: 1.2), 45.8 % (SD: 22.4), and 19.6 % (SD: 12.6) when doses were prescribed to PTV MR  (p = 0.028, p = 0.002 and p = 0.004, respectively).    Conclusions : TRUS/MRI fusion provides important information for prostate brachytherapy, allowing for better coverage and higher doses to extracapsular disease in patients with clinical stage T3a.",
author="Gomez-Iturriaga, Alfonso
and Crook, Juanita
and Casquero, Francisco
and Carvajal, Claudia
and Urresola, Arantxa
and Canteli, Begońa
and Ezquerro, Ana
and Hortelano, Eduardo
and Cacicedo, Jon
and Espinosa, Jose Maria
and Perez, Fernando
and Minguez, Pablo
and Bilbao, Pedro",
pages="154--160",
doi="10.5114/jcb.2014.43299",
url="http://dx.doi.org/10.5114/jcb.2014.43299"
}