@Article{Yu2014,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="65",
number="2",
year="2014",
title="The influence of Th1/Th2 and CD4+ regulatory t cells of mesenteric lymph nodes on systemic lipopolysaccharide",
abstract="Our aims were to study the influence of the mesenteric lymph nodes (MLN) of rats on systemic lipopolysaccharide and to identify the factor that affects the intestinal endotoxin translocation.   Ninety-six male Wistar rats were randomly divided into a sham-operation group (S group) and a cecal ligation and perforation group (CLP group). Twenty-four hours after modeling, we tested the Th1/Th2 ratio and percentage of CD4 + CD25 + Foxp3 +  Treg in the MLN. At the same time, the lipopolysaccharide (LPS) in the abdominal aortic blood was detected.   In the CLP group, the Th1/Th2 ratio was obviously lower than in the S group. Otherwise, the percentage of CD4 + CD25 + Foxp3 +  Treg of the CLP group was significantly higher than the S group. In the abdominal aortic blood, the LPS level of the CLP group was also higher than in the S group. Through correlation analysis, we found that the level of LPS was positively correlated with the percentage of CD4 + CD25 + Foxp3 +  Treg, and negatively correlated with the Th1/Th2 ratio.   This model reveals that the immune suppression of the MLN might affect the level of LPS in the abdominal aortic blood, which might play a certain role in affecting the endotoxin translocation.",
author="Yu, Wenli
and Du, Hongyin
and Fu, Qiang
and Cui, Naiqiang
and Du, Chao",
pages="125--129",
doi="10.5114/pjp.2014.43962",
url="http://dx.doi.org/10.5114/pjp.2014.43962"
}