@Article{Dabidi Roshan2013,
journal="Biology of Sport",
issn="0860-021X",
volume="30",
number="1",
year="2013",
title="Original paperENDURANCE EXERCISE TRAINING AND
DIFERULOYL METHANE SUPPLEMENT:
CHANGES IN NEUROTROPHIC FACTOR AND
OXIDATIVE STRESS INDUCED BY LEAD IN
RAT BRAIN",
abstract="Lead is a highly neurotoxic agent that particularly affects the developing central nervous system.  In the current study we investigated the neuroprotective effects of exercise training and/or diferuloyl methane  (DM) supplement, which is known as curcumin, on lead acetate-induced neurotoxicity in the rat hippocampus.  Sixty rats were randomly divided into six groups: 1) lead acetate, 2) DM supplement, 3) endurance training,  4) training+ DM supplement, 5) sham and 6) base. The rats in the training groups performed treadmill running  consisting of 15 to 22 m · min-1 for 25 to 64 min, 5 times a week for 8 weeks. All groups except sham received  lead acetate (20 mg · kg-1), whereas the sham group received DM solvent. In addition, the DM and training+DM  groups received DM solution (30 mg · kg-1) intraperitoneally. Chronic administration of lead acetate resulted in  a significant increase in the malondialdehyde (MDA) in plasma, but not in the hippocampus. In addition, it led  to significantly decreased brain-derived neurotrophic factor (BDNF) in the hippocampus and total antioxidant  capacity (TAC) levels, as compared to the sham group. Treadmill running, DM supplementation, or both resulted  in a significant decrease in MDA levels and significantly increased BDNF and TAC levels, as compared to the  lead acetate group. These results provide a rationale for an inhibitory role of DM supplement and regular exercise  in the attenuation of lead-induced neurotoxicity.",
author="Dabidi Roshan, V.
and Hosseinzadeh, S.
and Mahjoub, S.
and Hosseinzadeh, M.
and Myers, J.",
pages="41--46",
url="https://www.termedia.pl/Original-paper-ENDURANCE-EXERCISE-TRAINING-AND-r-nDIFERULOYL-METHANE-SUPPLEMENT-r-nCHANGES-IN-NEUROTROPHIC-FACTOR-AND-r-nOXIDATIVE-STRESS-INDUCED-BY-LEAD-IN-r-nRAT-BRAIN,78,23227,1,1.html"
}