@Article{Stępień-Słodkowska2013,
journal="Biology of Sport",
issn="0860-021X",
volume="30",
number="1",
year="2013",
title="Original paperTHE +1245G/T POLYMORPHISMS IN
THE COLLAGEN TYPE I ALPHA 1 (COL1A1)
GENE IN POLISH SKIERS WITH ANTERIOR
CRUCIATE LIGAMENT INJURY",
abstract="Objectives: The aim of this study was to examine the association of +1245G/T polymorphisms in  the COL1A1 gene with ACL ruptures in Polish male recreational skiers in a case-control study. Methods: A total  of 138 male recreational skiers with surgically diagnosed primary ACL ruptures, all of whom qualified for ligament  reconstruction, were recruited for this study. The control group comprised 183 apparently healthy male skiers  with a comparable level of exposure to ACL injury, none of whom had any self-reported history of ligament or  tendon injury. DNA samples extracted from the oral epithelial cells were genotyped for the +1245G/T polymorphisms  using real-time PCR method. Results: Genotype distributions among cases and controls conformed to Hardy-  Weinberg equilibrium (p=0.2469 and p=0.33, respectively). There was a significant difference in the genotype  distribution between skiers and controls (p=0.045, Fisher’s exact test). There was no statistical difference in  allele distribution: OR 1.43 (0.91-2.25), p=0.101 (two-sided Fisher’s exact test). Conclusions: The risk of ACL  ruptures was around 1.43 times lower in carriers of a minor allele G as compared to carriers of the allele T.",
author="Stępień-Słodkowska, M.
and Ficek, K.
and Eider, J.
and Leońska-Duniec, A.
and Maciejewska-Karłowska, A.
and Sawczuk, M.
and Zarębska, A.
and Jastrzębski, Z.
and Grenda, A.
and Kotarska, K.
and Cięszczyk, P",
pages="57--60",
url="https://www.termedia.pl/Original-paper-THE-1245G-T-POLYMORPHISMS-IN-r-nTHE-COLLAGEN-TYPE-I-ALPHA-1-COL1A1-r-nGENE-IN-POLISH-SKIERS-WITH-ANTERIOR-r-nCRUCIATE-LIGAMENT-INJURY,78,23230,1,1.html"
}