@Article{Khoshkhahesh2013,
journal="Biology of Sport",
issn="0860-021X",
volume="30",
number="1",
year="2013",
title="Original paperINFLUENCE OF A LOW-DOSE COX-2 INHIBITOR
DRUG ON EXERCISE-INDUCED INFLAM-
MATION, MUSCLE DAMAGE AND LIPID
PEROXIDATION",
abstract="The purpose of this study was to examine the effect of acute low-dose celecoxib administration on  exercise-induced inflammation, muscle damage and lipid peroxidation. Twenty healthy untrained males (age:  25.5±4.5 yrs, weight: 72.7±7.9 kg, height: 177.3±7.2 cm) were randomly assigned to treatment (T) or placebo  (P) groups. Blood samples were obtained before, immediately after, 3 h after and 24 h after exercise. Subjects  ·  ran for 30 min at 75% VO2max on a treadmill. Participants consumed 100 mg celecoxib or a placebo immediately  after and 12 h after the immediately post-exercise blood sample. Total leukocytes, neutrophils, creatine kinase  (CK), C-reactive protein (CRP) and malondialdehyde (MDA) were assessed at each time point. Significant increases  in total leukocytes and neutrophils were observed 3 h after exercise in both groups (P<0.05). CK and CRP levels  were significantly increased immediately, 3 h and 24 h after exercise in both groups (P<0.05). A significant  increase in MDA was observed immediately after exercise in both groups (P<0.05); however, no significant  group differences were observed for MDA or CK. These findings suggest that inhibition of cyclo-oxygenase  activity with low-dose celecoxib does not affect exercise-induced inflammation, muscle damage, or lipid  peroxidation.",
author="Khoshkhahesh, F.
and Siahkuhain, M.
and Fisher, G.
and Nakhostin-Roohi, B.",
pages="61--65",
url="https://www.termedia.pl/Original-paper-INFLUENCE-OF-A-LOW-DOSE-COX-2-INHIBITOR-r-nDRUG-ON-EXERCISE-INDUCED-INFLAM-r-nMATION-MUSCLE-DAMAGE-AND-LIPID-r-nPEROXIDATION,78,23231,1,1.html"
}