@Article{Kim2015,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="19",
number="4",
year="2015",
title="The effect of Lactobacillus casei extract on cervical cancer cell lines",
abstract=" Aim of the study :  Lactobacillus casei  ( L. casei ) has been shown to inhibit the proliferation of several types of cancer  in vivo , but its effect on cervical cells has not been reported. We incubated cells of the human cervical cell lines Caski and HeLa with extracts of  L. casei  and investigated its effects on the growth of the cells and possible synergy with anticancer drugs.   Material and methods : Cell-free extracts of  L. casei  were prepared and purified. Cultures of Caski and HeLa cells adhering to tissue culture plates were treated with  L. casei  extract. The effects of  L. casei  extract on the growth of cancer cells and its possible synergy with anti-cancer drugs in cervical cancer cell lines were investigated. The cells were treated with  L. casei  extract alone, anti-cancer drugs alone [doxorubicin, paclitaxel, 5-fluorouracil (5-FU), and cisplatin], or  L. casei  extract plus anti-cancer drugs.   Results :  L. casei  extract had no significant effect on the growth rate of the two cell lines. Anti-cancer drugs alone induced growth inhibition, but there was no synergistic effect of  L. casei  extract on growth inhibition.   Conclusions :  L. casei  extract does not have a potent effect on the viability of cervical cancer cells  in vitro . In addition,  L. casei  extract has no synergistic effect on the inhibition of growth of cancer cells in the presence of anti-cancer drugs.",
author="Kim, Soo-Nyung
and Lee, Won Moo
and Park, Kyoung Sik
and Kim, Jong Bin
and Han, Dae Jong
and Bae, Jaeman",
pages="306--312",
doi="10.5114/wo.2014.45292",
url="http://dx.doi.org/10.5114/wo.2014.45292"
}