@Article{Liu2014,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="18",
number="5",
year="2014",
title="The correlation of expression of VEGF and EGFR with SUV of 18FDG-PET-CT in non-small cell lung cancer",
abstract=" Aim of the study : To explore the correlation of the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) with maximum standardised uptake value (SUV max ) of  18 FDG-PET-CT in non-small cell lung cancer (NSCLC).   Material and methods : Thirty patients received PET-CT imaging protocol first, and then all the patients underwent needle biopsy though CT guidance. The tumour tissue of each patient was taken from two biopsy areas: one area was SUV max  = 2.5–5, and the other was SUV max  > 5. Expression of VEGF and EGFR were detected and analysed by immunohistochemical staining.   Results:  The expressions of both VEGF and EGFR had no statistically significant correlation with SUV max  in age, gender, pathology, or differentiation (p > 0.05). The expressions of both VEGF and EGFR had statistically significant correllation with SUV max  in tumour size and clinical stage (p < 0.05). SUV max  correlated positively with VEGF and EGFR expressions (r = 0.879, p < 0.05).   Conclusions : SUV max  correlated positively with expressions of VEGF and EGFR (r = 0.879, p = 0.000; r = 0.839, and p = 0.000, respectively). This study may provide guidance for radiotherapy of NSCLC.",
author="Liu, Xiguang
and Zhang, Hongjun
and Yu, Xiaoyun
and Song, Tingting
and Huang, Peng
and Wang, Haichao
and Song, Shan-ai",
pages="334--339",
doi="10.5114/wo.2014.45308",
url="http://dx.doi.org/10.5114/wo.2014.45308"
}