@Article{Coskun2015,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="10",
number="1",
year="2015",
title="Treatment of hypertriglyceridemia-induced acute
pancreatitis with insulin",
abstract=" Introduction : Hypertriglyceridaemia (HT)-induced pancreatitis rarely occurs unless triglyceride levels exceed 1000 mg/dl. Hypertriglyceridaemia over 1,000 mg/dl can provoke acute pancreatitis (AP) and its persistence can worsen the clinical outcome. In contrast, a rapid decrease in triglyceride level is beneficial. Insulin-stimulated lipoprotein lipase is known to decrease serum triglyceride levels. However, their efficacy in HT-induced AP is not well documented.   Aim:  To present 12 cases of AP successfully treated by insulin administration.   Material and methods:  Three hundred and forty-three cases of AP were diagnosed at our clinic between 2005 and 2012. Twelve (3.5%) of these cases were HT-induced AP. Twelve patients who suffered HT-induced AP are reported. Initial blood triglyceride levels were above 1000 mg/dl. Besides the usual treatment of AP, insulin was administered intravenously in continuous infusion. The patients’ medical records were retrospectively evaluated in this study.   Results : Serum triglyceride levels decreased to < 500 mg/dl within 2–3 days. No complications of treatment were seen and good clinical outcome was observed.   Conclusions : Our results are compatible with the literature. Insulin may be used safely and effectively in HT-induced AP therapy. Administration of insulin is efficient when used to reduce triglyceride levels in patients with HT-induced",
author="Coskun, Ali
and Erkan, Nazif
and Yakan, Savas
and Yildirim, Mehmet
and Carti, Erdem
and Ucar, Deniz
and Oymaci, Erkan",
pages="18--22",
doi="10.5114/pg.2014.45412",
url="http://dx.doi.org/10.5114/pg.2014.45412"
}