@Article{Collet2015,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
year="2015",
title="ReviewHypoxia-shaped vascular niche for cancer stem cells",
abstract="The tumour microenvironment, long considered as determining cancer development, still offers research fields to define hallmarks of cancer. An early key-step, the “angiogenic switch”, allows tumour growth. Pathologic angiogene-sis is a cancer hallmark as it features results of tumour-specific properties that can be summarised as a response to hypoxia. The hypoxic state occurs when the tumour mass reaches a volume sufficient not to permit oxygen diffusion inside the tumour centre. Thus tumour cells turn on adaptation mechanisms to the low pO2 level, inducing biochemical responses in terms of cytokines/chemokines/receptors and consequently recruitment of specific cell types, as well as cell-selection inside the tumour. Moreover, these changes are orchestrated by the microRNA balance strongly reflecting the hypoxic milieu and mediating the cross-talk between endothelial and tumour cells. MicroRNAs control of the endothelial precursor-vascular settings shapes the niche for selection of cancer stem cells.",
author="Collet, Guillaume
and Hafny-Rahbi, Bouchra El
and Nadim, Mahdi
and Tejchman, Anna
and Klimkiewicz, Krzysztof
and Kieda, Claudine",
pages="39--43",
doi="10.5114/wo.2014.47130",
url="http://dx.doi.org/10.5114/wo.2014.47130"
}