@Article{Nowak2014,
journal="Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery",
issn="1731-5530",
volume="11",
number="4",
year="2014",
title="HEART AND LUNG FAILURE, TRANSPLANTOLOGYThe relationship between late gadolinium enhancement imaging and myocardial biopsy in the evaluation of chronic heart failure patients with suspected myocarditis",
abstract=" Aim:  The aim of this study was to assess the relationship between late gadolinium-enhanced (LGE) cardiovascular magnetic resonance (CMR) and immunohistochemical markers of inflammation in patients with heart failure and a reduced ejection fraction (HFrEF).    Material and methods : Endomyocardial biopsy and CMR were performed in 38 consecutive patients (24 males, average age 43.2 ± 6.9 years, New York Heart Association [NYHA] class II) with HFrEF and suspected myocarditis. The immunohistochemical evaluation was done by the En-Vision system using DAKO monoclonal antibodies. The presence of > 14 infiltrating cells together with myocardial damage and ≥ 2 + up-regulation of HLA class II was considered diagnostic for myocarditis. The results of LGE were compared with the immunohistochemical markers of inflammation. All patients underwent coronary angiography.    Results:  Twelve out of 38 (31.6%) patients met the immunohistological criteria for the diagnosis of myocarditis. Late gadolinium enhancement was present in 23 of 38 (60.5%) patients, mostly at the interventricular septum. No correlation was found between LGE and immunohistochemistry results (Kendall’s tau; r = 0.21, p = 0.09).   Conclusions:  Our study revealed no significant relationship between LGE cardiovascular magnetic resonance imaging and immunohistochemical markers of inflammation in patients with HFrEF.",
author="Nowak, Jolanta
and Wasilewski, Jarosław
and Reichman-Warmusz, Edyta
and Spinczyk, Beata
and Głowacki, Jan
and Miszalski-Jamka, Karol
and Szyguła-Jurkiewicz, Bożena
and Tajstra, Mateusz
and Badziński, Arkadiusz
and Wojnicz, Romuald
and Poloński, Lech",
pages="404--408",
doi="10.5114/kitp.2014.47340",
url="http://dx.doi.org/10.5114/kitp.2014.47340"
}