@Article{Woźniakowska2004,
journal="Menopause Review/Przegląd Menopauzalny",
issn="1643-8876",
volume="3",
number="4",
year="2004",
title="The serum interleukin-6 levels in the early postoperative period after surgical castration \– the influence of ERT",
abstract="Background. The role of inflamation in the pathogenesis of cardiovascular disease (CVD) has been well established. Measurement of the proinflamatory cytokines such as interleukin-6 (IL-6) has been recommended for determining the risk of CVD. Women with surgical menopause (due to biletaral salpingo-oophorectomy) are susceptible to vascular complications related to thrombogenesis and atherogenesis. Estradiol deficiency promotes bone loss through increasing interleukin-6 activity.  Purpose of the study. The aim of our study was to evaluate the impact of surgical menopause on serum Il-6 concentration including the effect of early initiated estrogen replacement therapy (ERT).  Material and methods. Twenty five premenopausal women (mean age 49\&plusmn;2,6 years) undergoing total abdominal hysterectomy with bilateral oophorectomy (TAH\&BSO) were studied. IL-6 concentrations were measured in venous blood serum by means of ELISA assay in three time points: before the operation, in the postoperative day 2 and in postoperative day 3 (24 hours after starting ERT in the form of transdermal 17b -estradiol - 100 mg/24h; Estraderm TTS 100, Novartis).  Results. In the postoperative day 2 a highly statistically significant (p < 0.001) increase in IL-6 levels was observed as compared to preoperative values. In the 3rd postoperative day, twenty four hours after the initiation of ERT, a strongly significant (p<0.001) decrease in IL-6 concentration was observed as compared to postoperative day-2 levels.  Conclusions. Surgical castration results in the immediate, almost 8-fold increase in IL-6 level. Early initiation of ERT after TAH\&BSO decreases the IL-6 concentration after 24 hours of estrogen supplementation which may have both cardioprotective and osteoprotective consequences.",
author="Woźniakowska, Ewa
and Donica, Helena
and Paszkowski, Tomasz",
pages="22--25",
url="https://www.termedia.pl/The-serum-interleukin-6-levels-in-the-early-postoperative-period-after-surgical-castration-8211-the-influence-of-ERT,4,2479,1,1.html"
}