@Article{García2015,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="53",
number="1",
year="2015",
title="Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease",
abstract=" The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson’s disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 patients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp() = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD. ",
author="García, Silvia
and Coral-Vázquez, Ramón Mauricio
and Gallegos-Arreola, Martha P.
and Montes-Almanza, Luis Ángel
and Canto, Patricia
and García-Martínez, Froylan Arturo
and Chavira-Hernández, Gerardo
and Palma-Flores, Carlos
and Dávila-Maldonado, Luis
and Cuevas-García, Carlos F.
and Hernández, Luz Berenice López",
pages="24--28",
doi="10.5114/fn.2015.49971",
url="http://dx.doi.org/10.5114/fn.2015.49971"
}