@Article{Pirowska2015,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="32",
number="4",
year="2015",
title="Original paperAutoimmunogenicity during anti-TNF therapy in patients with psoriasis and psoriatic arthritis",
abstract=" Introduction:  The tumor necrosis factor (TNF-α) was initially described as lymphotoxin or cachectin. The discovery of therapies blocking the action of TNF-α, in 1988, started a new era in the therapy. One of often reported adverse effects related to the use of TNF-α antagonists is induction of the formation of autologous antibodies and antibodies neutralizing anti-TNF drugs. The development of anti-TNF-induced lupus or classical drug-induced lupus is more rarely reported.   Aim:  To evaluate the presence and the level of anti-nuclear antibodies in patients with psoriasis and psoriatic arthritis and the influence of anti-TNF therapy used on the concentration of antinuclear antibody (ANA).   Material and methods:  A total of 28 subjects were included in the study. 71.4% of subjects were diagnosed with psoriatic arthritis and 28.6% with plaque psoriasis.   Results : Among the patients with plaque psoriasis, the antinuclear antibodies were found in 25% of subjects and in 80% of patients with psoriatic arthritis. After the treatment an increase in the titer or appearance of antibodies was found in 66.7% in the infliximab group, 18.2% in the etanercept group and 54.7% in the adalimumab group. No subjects developed symptoms of drug-induced systemic lupus.   Conclusions : Our findings have shown that all anti-TNF therapies induced ANA in psoriatic arthritis and psoriatic patients. Considering a mild course of lupus induced by anti-TNF treatment and, usually intrinsic, resolution of symptoms, the biological therapy still appears as a safe treatment for patients.",
author="Pirowska, Magdalena M.
and Goździalska, Anna
and Lipko-Godlewska, Sylwia
and Obtułowicz, Aleksander
and Sułowicz, Joanna
and Podolec, Katarzyna
and Wojas-Pelc, Anna",
pages="250--254",
doi="10.5114/pdia.2015.53320",
url="http://dx.doi.org/10.5114/pdia.2015.53320"
}