@Article{K. Olejnik2003,
journal="Central European Journal of\ Immunology",
issn="1426-3912",
volume="28",
number="4",
year="2003",
title="Interleukin 4 (IL-4) influences rat mast cell releasability",
abstract="There is growing evidence that cytokines may regulate biological functions of mature mast cells. In the following study we have investigated the capacity of IL-4 to induce direct mediator release from rat peritoneal mast cells as well as the action of this cytokine on mast cell secretory activity. We have determined that IL-4 does not activate rat mast cells to secretion of histamine and serotonin. We have also noticed that culture of these cells for 3 or 6 hours in the presence of IL-4 does not result in the IL-2 secretion. Yet, the results of our experiments have clearly shown that IL-4 treatment for 30 min causes the decrease of spontaneous histamine release from rat mast cells (up to 57.8% of maximal value at concentration of IL-4 100 ng/ml) and this decrease is statistically significant. Moreover, we have noticed that treatment of mast cells with IL-4 significantly inhibits compound 48/80-induced histamine release. IL-4 treatment does not change the reactivity of mast cells to ConA- and anti-IgE-stimulation. These results indicate that although IL-4 does not appear to be a direct stimulus for mediator release from mature rat mast cells, it may influence mast cell secretory activity.",
author="K. Olejnik, Alicja
and Brzezińska-Błaszczyk, Ewa",
pages="173--180",
url="https://www.termedia.pl/Interleukin-4-IL-4-influences-rat-mast-cell-releasability,10,2570,1,1.html"
}