@Article{Janulionis2015,
journal="Journal of Contemporary Brachytherapy",
issn="1689-832X",
volume="7",
number="5",
year="2015",
title="Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute",
abstract=" Purpose:   The purpose of this paper was to observe and compare long-term curative effects and complications of FIGO stage IIB cervical cancer patients (n = 232) treated with high-dose-rate (HDR) californium ( 252 Cf) neutron or cobalt ( 60 Co) photon intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT).    Material and methods:   The EBRT dose to the small pelvis was 50 Gy in both groups. The brachytherapy component of  252 Cf or  60 Co was added in the 3 rd  week of EBRT, 5 fractions were performed once per week resulting in a total ICBT dose of 40 Gy/Gy eq  (point A).    Results:   Overall survival (OS) at 5, 10 and 15 years was 63.6%, 50.4% and 38.8% in the  252 Cf group and 62.2%, 50.5%, 39.9%, in the  60 Co group, respectively (p = 0.74). The percentage of tumour recurrence was statistically significantly lower in the  252 Cf group with 7.4 %  versus  17.1% in the  60 Co group (p = 0.02). Second primary cancers have developed similarly 9.1% and 8.1% cases for  252 Cf and  60 Co groups, respectively.    Conclusions : Our long-term retrospective study comparing  252 Cf and  60 Co isotopes with brachytherapy in combined treatment of FIGO IIB stage cervix carcinoma patients shows, that overall survival in the both groups are similar. However, the recurrence of tumour was significantly lower in the",
author="Janulionis, Ernestas
and Valuckas, Konstantinas Povilas
and Liukpetryte, Sarune
and Samerdokiene, Vitalija
and Atkocius, Vydmantas",
pages="346--351",
doi="10.5114/jcb.2015.55117",
url="http://dx.doi.org/10.5114/jcb.2015.55117"
}