@Article{Sobjanek2016,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="33",
number="4",
year="2016",
title="Soluble interleukin-2 receptor α and interleukin-2 serum levels in patients with basal cell carcinoma",
abstract=" Introduction:  Basal cell carcinoma (BCC) is an immunogenic neoplasm and the imbalance in Th1/Th2 cytokines expression seems to play the major role in pathogenesis and clinical behaviour of the tumour.    Aim : To investigate the association of soluble interleukin 2α receptor (sIL-2Rα) and interleukin-2 (IL-2) serum concentrations with BCC.   Material and methods : The study involved 110 individuals with BCC and 60 healthy age- and sex-matched volunteers. Serum levels of sIL-2Rα and IL-2 were measured using ELISA test.   Results : We found significantly (p = 0.027) increased sIL-2Rα serum levels in BCC patients, in comparison to healthy controls. Statistically (p = 0.04) higher sIL-2Rα levels were observed in patients with more advanced tumours. Serum levels of sIL-2Rα showed a significant linear (r = 0.24, p = 0.018) correlation with tumour size. The average IL-2 serum levels in BCC patients were statistically (p = 0.039) decreased compared to controls. Significantly (p = 0.0454) lower median IL-2 levels were observed in patients with more advanced tumours. A negative correlation between sIL-2Rα and IL-2 serum concentrations was revealed (r = –0.22; p = 0.027).    Conclusions : Our results testify to the importance of the IL-2/sIL-2Rα signalling pathway in pathogenesis of BCC, suggesting that IL-2 and sIL-2Rα might be considered as potential markers of disease and targets for immunotherapy in BCC patients.",
author="Sobjanek, Michal
and Bien, Ewa
and Zablotna, Monika
and Sokolowska-Wojdylo, Malgorzata
and Sikorska, Monika
and Lange, Magdalena
and Nowicki, Roman",
pages="263--268",
doi="10.5114/pdia.2015.55177",
url="http://dx.doi.org/10.5114/pdia.2015.55177"
}