@Article{Pepe2015,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="19",
number="6",
year="2015",
title="Gleason score stratification according to age at diagnosis in 1028 men",
abstract=" Aim of the study : Gleason score stratification according to age at diagnosis has been retrospectively evaluated in 1028 men with biopsy-proven prostate cancer (PCa).   Material and methods : From January 2006 to December 2014, 2435 Caucasian men aged between 37 and 92 years underwent transperineal prostate biopsy for suspicion of PCa. The indications were as follows: abnormal digital rectal examination (DRE), PSA values > 10 ng/ml or between 4.1–10 or 2.6–4 ng/ml, with free/total PSA < 25% and < 20%, respectively.   Results : In 1028 (42.2%) patients with median PSA of 9.6 ng/ml a PCa was found (median age 62.3 years; range: 42–92 years); 757 (73.7%) vs. 271 (26.3%) men had a T1c vs. T2 clinical stage, respectively. Median Gleason score was 7 (range: 6–10). The Gleason score progressively increased with the age of the patients at diagnosis, and a significantly correlation between Gleason score  8 and men older than 80 years was demonstrated (p = 0.0001).   Conclusions : The detection rate of aggressiveness of PCa progressively increased with the age at diagnosis; Gleason score  8 was more frequently diagnosed in men older than 80 years with PSA values > 10 ng/ml (about 80% of the cases) and abnormal DRE (about 60% of the cases).",
author="Pepe, Pietro
and Pennisi, Michele",
pages="471--473",
doi="10.5114/wo.2015.56654",
url="http://dx.doi.org/10.5114/wo.2015.56654"
}