@Article{Işık2016,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="33",
number="6",
year="2016",
title="Is there any increased risk of hypertension, diabetes and cardiac diseases in psoriatic patients with TNF-α G238A and G308A polymorphism?",
abstract=" Introduction : Psoriasis is regarded as a complex autoimmune disease with strong genetic background. Psoriatic patients suffer from many comorbidities including hypertension, diabetes and cardiovascular diseases. Cytokines such as tumor necrosis factor α (TNF-α) may be a key player that triggers psoriasis and diabetes, hypertension and cardiac disease at the same time.   Aim:   To evaluate genetic variations in the TNF-α region and its association with psoriasis and related comorbidities.   Material and methods : The study covered 129 psoriasis patients with three main subgroups with coronary artery disease (n = 41), hypertension (n = 35), and diabetes (n = 21). DNA samples were genotyped for TNF-α G308A and G238A polymorphisms by real-time polymerase chain reaction melting-curve analysis and results were compared statistically.   Results : Psoriatic patients with both TNF-α-298 and TNF-α-308 polymorphisms showed no statistically significant increase in the risk of hypertension (OR = 0.425, χ 2  = 1.76, p = 0.18 and OR = 1.87,χ 2  = 1.33, p = 0.25), coronary artery disease (OR = 1.97, χ 2  = 1.91, p = 0.17 and OR = 2.63, χ 2  = 1.35, p = 0.25), or diabetes (OR = 1.35, χ 2  = 0.24, p = 0.62 and OR = 1.53, χ 2  = 0.24, p = 0.62).   Conclusions : The current preliminary results suggested that there was no correlation between TNF- promoter polymorphism and diabetes, hypertension and cardiac disease among psoriatic patients in the Turkish population.",
author="Işık, Selda
and Hiz, Meliha Merve
and Kılıç, Sevilay
and Öğretmen, Zerrin
and SIlan, Fatma",
pages="440--444",
doi="10.5114/pdia.2016.58384",
url="http://dx.doi.org/10.5114/pdia.2016.58384"
}