@Article{Kalińska-Bienias2016,
journal="Dermatology Review/Przegląd Dermatologiczny",
issn="0033-2526",
volume="103",
number="2",
year="2016",
title="The role of analysis of EVER2 haplotypes in actinic keratosis",
abstract=" Introduction . Polymorphisms of  EVER  genes are related to increased risk of actinic keratosis (AK), squamous skin cancers (SCC) and cervical cancer.    Objective . The aim of this study was to analyze the haplotypes of the   EVER 2  gene in 65 subjects with ≥ 5 actinic keratoses and in 274 controls. The correlations between   EVER 2  haplotype and selected clinical parameters in patients with actinic keratosis were also evaluated.   Material and methods . The analysis involved polymorphisms –917A>T (rs7208422), –988-4G>T (rs62079073) and –1107G>A (rs12452890), which obtained statistically significant results in previous published studies of patients with actinic keratosis and squamous skin cancers. The full blood samples of patients and controls were genotyped using real-time polymerase chain reaction with reagents from Applied Biosystems.    Results . In a group of patients with AK and the controls the most frequent haplotypes were AGG and TGA. Haplotype TG (–917A>T and –988-4G>T) containing the promoter T allele of 917A>T was more frequent in patients who had AK onset before the age of 70 years (0.6117 vs. 0.417; p = 0.029) and with more extensive skin lesions (0.6085 vs. 0.414; p = 0.029). Haplotype TA (–988-4G>T and –1107G>A), containing the protective G allele of –988-4G>T, was observed only in patients with AK. There was no presence of haplotype TA in patients with coexisting SCC (the result was near statistical significance, p = 0.059).   Conclusions . The results of the study suggest the necessity of analysis of haplotypes in evaluation of predisposition to precancerous skin lesions and skin cancers.",
author="Kalińska-Bienias, Agnieszka
and Kostrzewa, Grażyna
and Malejczyk, Magdalena
and Płoski, Rafał
and Majewski, Sławomir",
pages="102--108",
doi="10.5114/dr.2016.59131",
url="http://dx.doi.org/10.5114/dr.2016.59131"
}