@Article{Marcinkiewicz2016,
journal="Dermatology Review/Przegląd Dermatologiczny",
issn="0033-2526",
volume="103",
number="2",
year="2016",
title="The role of antimicrobial peptides in skin tumorigenesis",
abstract="Antimicrobial peptides (AMPs), known as “natural antibiotics”, are the first line of defense in humans as effector molecules of the innate immune system of the skin. They present activity against a broad spectrum of bacteria, fungi, parasites and enveloped viruses. An increasing number of studies report altered expression of AMPs in human cancers. Antimicrobial peptides such as human β defensins, human cathelicidin, ribonuclease 7 and psoriasin, a member of S100 proteins, are suggested to play a role in tumor progression and tumor suppression in pre-malignant skin lesions and malignancies. Noticeable changes in AMPs expression in skin tumorigenesis suggest a correlation between peptides and cutaneous cancers, though it is still a matter of discussion. In this article we review recent studies on the relationship between antimicrobial peptides and skin tumorigenesis.",
author="Marcinkiewicz, Małgorzata
and Majewski, Sławomir",
pages="162--168",
doi="10.5114/dr.2016.59139",
url="http://dx.doi.org/10.5114/dr.2016.59139"
}