@Article{Sałkowska-Wanat2016,
journal="Dermatology Review/Przegląd Dermatologiczny",
issn="0033-2526",
volume="103",
number="3",
year="2016",
title="An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers",
abstract=" Introduction.   Human papillomaviruses (HPV) consist of more than 120 subtypes of viruses, which can be divided into three main groups: skin subtypes, mucosal subtypes and types responsible for the occurrence of the skin lesions in autosomal recessive disorders such as  epidermodysplasia verruciformis .   Objective . The aim of the study was to evaluate the correlation between the occurrence of  epidermodysplasia verruciformis  and the development of genital cancers.   Case report.   We analyzed the case of a young woman suffering from  epidermodysplasia verruciformis  from 6 years of age, who at the age of 20 developed genital cancers with a severe clinical course resulting in amputation of the uterus, cervix, the top of the vagina and labia major and minor. In the patient we found a mutation in the EVER2 gene and we revealed the presence of EV-HPV type 5, 9, 17, and 20 in unusual genital locations associated with genital cancers.   Conclusions . It is possible that in the presented case the rapid and severe course of genital cancers was related to mutation in the EVER2 gene.",
author="Sałkowska-Wanat, Joanna M.
and Trzeciak, Leszek
and Smolarczyk, Katarzyna
and Pniewski, Tomasz
and Płoski, Rafał
and Majewski, Sławomir",
pages="218--221",
doi="10.5114/dr.2016.60626",
url="http://dx.doi.org/10.5114/dr.2016.60626"
}