@Article{Jakubowska2016,
journal="Family Medicine \& Primary Care Review",
issn="1734-3402",
volume="18",
number="2",
year="2016",
title="Usefulness of urinary kidney injury molecule-1 (KIM-1) in children with idiopathic nephrotic syndrome treated with cyclosporine A",
abstract=" Background . Some forms of idiopathic nephrotic syndrome (INS ) are treated with cyclosporine A (CsA) as an alternative method. A serious adverse effect of the drug is nephrotoxicity. To help optimize the therapy, researchers are looking for early kidney injury markers.   Objectives.   To determine KI M-1 (kidney injury molecule-1) plasma and urine concentrations in children with INS and to evaluate the suitability of the protein as CsA nephrotoxicity marker.   Material and methods.   30 children with steroid-dependent (SDNS ) and steroid-resistant (SRNS ) INS and 22 healthy children were enrolled to the study. KI M-1 plasma and urine concentrations were determined in children with INS before the administration of CsA, and then after 6 and 12 months, using the enzyme-linked immunosorbent assay (ELISA ).   Results.   In the INS group, higher KI M-1 plasma and urine concentration were observed prior to the administration of CsA compared to the reference group. During the follow-up period, KI M-1 plasma levels were increasing, and the values varied significantly at all time points. KI M-1 urine levels after 6 and 12 months of therapy were significantly higher compared to baseline, and statistically, did not vary significantly when determined between 6 and 12 months of treatment. No correlation was found between KI M-1 urine concentrations and CsA blood levels, proteinuria or eGFR. The parameters analysed in plasma and urine of SDNS and SRNS diagnosed patients, did not vary significantly.   Conclusions . Urine KI M-1 concentration were found to vary in INS children treated with CsA, which suggests that the protein may be suitable for monitoring these patients.",
author="Jakubowska, Anna
and Zwolińska, Danuta
and Kiliś-Pstrusińska, Katarzyna",
pages="103--108",
doi="10.5114/fmpcr/60510",
url="http://dx.doi.org/10.5114/fmpcr/60510"
}