@Article{Czapiewski2016,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="67",
number="3",
year="2016",
title="Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma",
abstract="Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide. Alterations in keratin expression, including keratin 7 (K7), are frequent findings in multiple cancers, and they constitute a prognostic factor. The aim of our study was to evaluate the prognostic significance of K7 in the primary tumour and lymph node metastases in two separate cohorts of patients: the first one with lymph node involvement (LN+, 129 cases) and the second one free of LN metastases (LN–, 85 cases).   Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN– group.   K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival.   We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.",
author="Czapiewski, Piotr
and Bobowicz, Maciej
and Pęksa, Rafał
and Skrzypski, Marcin
and Gorczyński, Adam
and Szczepańska-Michalska, Kamila
and Korwat, Aleksandra
and Jankowski, Michał
and Zegarski, Wojciech
and Szulgo-Paczkowska, Anna
and Polec, Tomasz
and Piątek, Michał
and Skokowski, Jarosław
and Haybaeck, Johannes
and Żaczek, Anna
and Biernat, Wojciech",
pages="228--234",
doi="10.5114/pjp.2016.63774",
url="http://dx.doi.org/10.5114/pjp.2016.63774"
}