@Article{Gómez-Álvarez2017,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="12",
number="3",
year="2017",
title="Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability",
abstract=" Introduction:   Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance. Microsatellite instable (MSI) colorectal carcinomas have demonstrated better prognosis in clinical stage II.    Aim:  To analyze the survival and clinicopathological characteristics of MCs versus PDAs with MSI in clinical stage III.   Material and methods:  We studied 22 cases of PDAs with MSI versus 10 MCs.   Results : Of the 10 MCs, 7 patients were men; the mean age was 57.8 ±5.6 years. The mean tumor size was 9.6 ±4.1 cm, and the primary site was the right colon in 9; 7 patients showed lymph node metastases (LNM) and lymphovascular invasion (LVI). Of the 22 PDA cases, 12 (54.5%) were women with a mean age of 75 ±16.1 years. The mean tumor size was 6.4 ±3.2 cm. Twelve (54.5%) presented in the right colon, 21 (95.5%) showed LNM and 7 (31.8%) LVI. Follow-up was 32 ±8 months, with a 5-year overall survival of 42.9% for MCs and 76.6% for PDAs (p = 0.048). Univariate analysis found local recurrence (p = 0.001) and medullary subtype (p = 0.043) associated with lower survival.    Conclusions : Medullary carcinomas were of greater tumor size and associated with more LVI and worse survival versus PDAs with MSI in stage III.",
author="Gómez-Álvarez, Miguel A.
and Lino-Silva, Leonardo S.
and Salcedo-Hernández, Rosa A.
and Padilla-Rosciano, Alejandro
and Ruiz-García, Erika B.
and López-Basave, Horacio N.
and Calderillo-Ruiz, German
and Aguilar-Romero, José M.
and Domínguez-Rodríguez, Jorge A.
and Herrera-Gómez, Ángel
and Meneses-García, Abelardo",
pages="208--214",
doi="10.5114/pg.2016.64740",
url="http://dx.doi.org/10.5114/pg.2016.64740"
}