@Article{Kommavarapu2016,
journal="HIV \& AIDS Review. International Journal of HIV-Related Problems",
issn="1730-1270",
volume="15",
number="4",
year="2016",
title="Preparation and characterization of Efavirenz nanosuspension with the application of enhanced solubility and dissolution rate",
abstract=" Aim   Intend of the present exertion is to prepare β-cyclodextrin (β-CD) based polymeric nanosuspension (PNS) of Efavirenz (EFV) with enhanced aqueous solubility and dissolution rate as compared to pure drug.     Background   EFV is a low aqueous soluble molecule because of which there is drug absorption problem. To overcome this problem polymeric nanosuspension were prepared using precipitation method which produced successful results.     Materials and methods   Four formulations (β-CDPNS1, β-CDPNS2, β-CDPNS3 and β-CDPNS4) with varying drug-polymer ratios were prepared by precipitating drug-polymer physical mixtures dissolved in organic phase in an aqueous phase. Solid state characterization of β-CDPNS's were conducted using X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy-universal attenuated total reflectance (FTIR-UATR), and scanning electron microscopy (SEM) to examine physical properties and to study the compatibility of EFV with pharmaceutical excipients. Dynamic light scattering (DLS) studies was performed for nanoparticles evaluation.     Results   The mean diameter of the nanoparticles ranged between 143.8 and 284.4 nm and polydispersity index (Pdi) values for all the nanosuspensions were small ( 60% in each formulation.     Conclusion   Successful preparation and characterization of Efavirenz nanosuspension by solvent injection method has been accomplished in this study.",
author="Kommavarapu, Pavan
and Maruthapillai, Arthanareeswari
and Palanisamy, Kamaraj",
pages="170--176",
url="https://www.termedia.pl/Preparation-and-characterization-of-Efavirenz-nanosuspension-with-the-application-of-enhanced-solubility-and-dissolution-rate,106,29068,1,1.html"
}