@Article{Ziemiańska2016,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="20",
number="6",
year="2016",
title="Repeated nondiagnostic result of thyroid fine-needle aspiration biopsy",
abstract=" Aim of the study:   Fine-needle aspiration biopsy (FNAB) is the most accurate and cost-effective method to evaluate the risk of malignancy of thyroid nodules, but approximately 1–24% of FNABs generate a nondiagnostic result (ND-FNAB). The aim of this study was to determine the predictive factors of a repeated nondiagnostic result of FNAB.   Material and methods : A total of 4018 FNABs performed in a territorial referral centre were analysed, of which 288 (7.17%) were nondiagnostic. Medical records were available for 245 biopsies performed in 228 patients. The retrospective analysis of factors that may influence a repeat ND-FNAB, including demographic, clinical and ultrasound characteristics, was performed.   Results : A repeat FNAB was performed in 159 nodules giving a diagnostic result in 79.2% of cases. The time between the biopsies ranged from 1 to 611 days (mean 154.4, median 119). The timing of a repeat FNAB did not significantly alter the diagnostic output (p = 0.29). In the univariate analysis, significant predictors of a repeat ND-FNAB were older patient age (p = 0.02), L-thyroxine supplementation (p = 0.05), and a history of  131 I therapy (p < 0.0001). In the multivariate analysis, only a history of  131 I therapy was a statistically significant risk factor for a repeat ND-FNAB (p = 0.002).   Conclusions : Patients with a history of  131 I therapy and ND-FNAB should undergo periodic ultrasonographic assessment rather than a repeat biopsy. The interval between repeated FNABs recommended by guidelines does not affect the diagnostic output.",
author="Ziemiańska, Klaudia
and Kopczyński, Janusz
and Kowalska, Aldona",
pages="491--495",
doi="10.5114/wo.2016.65611",
url="http://dx.doi.org/10.5114/wo.2016.65611"
}