@Article{Su2017,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="34",
number="3",
year="2017",
title="The relationship between severity of disease and vitamin D levels in children with atopic dermatitis",
abstract=" Introduction : Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D is a liposoluble vitamin synthesized mainly in the skin. Vitamin D has several effects on the skin.    Aim : To assess the serum level of vitamin D in children with AD and determine its relation to AD severity.    Material and methods : Sixty patients with AD were enrolled in the study. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index. The control group consisted of 37 healthy subjects.    Results : The mean serum concentration of 25(OH)D3 in patients with AD was not statistically different from control subjects (p = 0.065). The vitamin D level was significantly lower in moderate and severe AD compared with mild AD, and this difference was statistically significant (p = 0.001 and p = 0.004). Vitamin D showed a negative correlation with serum total IgE levels (p = 0.007). There was no significant correlation between total IgE levels and SCORAD scores (p = 0.089).    Conclusions : This study suggests that a low serum vitamin D level is inversely associated with severity of AD in children. Vitamin D has not been included in the routine treatment of AD because of the conflicting results of various studies. Thus, there is a need for more detailed and prospective studies.",
author="Su, Ozlem
and Bahalı, Anıl Gülsel
and Demir, Ayşegül Doğan
and Ozkaya, Dilek Biyik
and Uzuner, Selçuk
and Dizman, Didem
and Onsun, Nahide",
pages="224--227",
doi="10.5114/pdia.2017.66054",
url="http://dx.doi.org/10.5114/pdia.2017.66054"
}