@Article{Bobeff2017,
journal="Folia Neuropathologica",
issn="1641-4640",
volume="55",
number="1",
year="2017",
title="Three cases of ectopic sphenoid sinus pituitary adenoma",
abstract="  Introduction : Ectopic sphenoid sinus pituitary adenoma is a rare tumour originating from embryologic remnants of Rathke’s pouch. Although it is considered a clinically benign neoplasm, necrosis is encountered in 25% of cases and it can invade adjacent bone structures.    Aims : To establish clinical, radiological and histopathological features of ectopic sphenoid sinus pituitary adenoma.   Material and methods:   Analysis of three cases: two females and one man, aged 61-70.    Results : One patient presented with a unilateral hearing loss, the other two with headache and vertigo. They all suffered from type 2 diabetes mellitus. Neurological examination revealed no abnormality. Radiological imaging showed a sphenoid sinus space-occupying soft-tissue lesion with bone erosion in 2 cases and empty sella in 2 patients whereas one had a normal pituitary gland. All were operated on via the transnasal approach. Total resection was achieved in one patient and subtotal in two; in two cases we observed intact sellar dura and in one intact sellar floor. Histopathology showed immunoreactivity for synaptophysin in all cases and cytokeratin in two. The Ki-67 index was less than 2%. Immunohistochemical staining demonstrated growth hormone cells in all cases whereas prolactin and adrenocorticotropin in two. The patients were discharged home in good condition with no neurological deficits.   Conclusions : Ectopic sphenoid sinus pituitary adenoma should always be considered in differential diagnosis of sphenoid sinus lesion in the elderly, especially in coexistence with empty sella or type 2 diabetes mellitus. Since ectopic sphenoid sinus pituitary adenoma is a benign lesion, surgical removal is an effective treatment.     ",
author="Bobeff, Ernest Jan
and Wiśniewski, Karol
and Papierz, Wielisław
and Stefańczyk, Ludomir
and Jaskólski, Dariusz Jan",
pages="60--66",
doi="10.5114/fn.2017.66714",
url="http://dx.doi.org/10.5114/fn.2017.66714"
}