@Article{Li2017,
journal="Journal of Contemporary Brachytherapy",
issn="1689-832X",
volume="9",
number="2",
year="2017",
title="Computed tomography-guided implantation of 125I seeds brachytherapy for recurrent multiple pulmonary oligometastases: initial experience and results",
abstract=" Purpose : To retrospectively evaluate the efficacy and safety of computed tomography (CT)-guided percutaneous interstitial brachytherapy using  125 I radioactive seeds for multiple pulmonary metastatic tumors.    Material and methods : Between September 2013 and December 2015, 22 patients with multiple pulmonary metastases, who after conventional chemotherapy and trans-arterial chemoembolization (TACE) therapy were considered unable to withstand stereotactic body radiation therapy (SBRT), received CT-guided  125 I brachytherapy. Clinical data were studied retrospectively. A planning target volume of 90% (D90) was 120-160 Gy for  125 I seeds with an activity of 25.9 MBq. A CT-based evaluation performed 1, 2, and 6 months’ post-implantation enabled review of local control of tumors.    Results : Twenty-two patients with 65 pulmonary metastases successfully completed treatment. The mean value for D90 for implantation for  125 I seeds was 132 Gy. Complete response (CR) + partial response (PR) was documented in 81.54%, 78.46%, and 78.46% of patients at 1, 2, and 6 months after implantation, respectively. Fourteen out of 22 patients had CR, 3 had PR, 2 had stable disease (SD), and 3 had progressive disease (PD). Most of the metastases (CR + PR + SD; 87.69% after 6 months) were controlled by implantation.    Conclusions : CT-guided  125 I brachytherapy is a safe and effective treatment for multiple pulmonary metastatic tumors, and can achieve good short-term local control, so long as the radiation dose is sufficient.",
author="Li, Jie
and Zhang, Lijuan
and Xu, Wenhuan
and Wang, Teng
and Zhou, Leyuan
and Xie, Qigen
and Wang, Weiguo
and Hua, Yanyan",
pages="132--138",
doi="10.5114/jcb.2017.67023",
url="http://dx.doi.org/10.5114/jcb.2017.67023"
}