@Article{Dyduch2017,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="34",
number="3",
year="2017",
title="CD207+/langerin positive dendritic cells in invasive and in situ cutaneous malignant melanoma",
abstract=" Introduction : Dendritic cells are crucial for cutaneous immune response. Their role in melanoma progression is however a matter of controversy.   Material and methods : The number of dendritic cells within epidermis and in peri- and intratumoral location was analyzed using CD207 immunostain in 17 cases of  in situ  and 25 case of invasive melanoma.   Results : Average peritumoral CD207+ cells count was 22.88 for all cases, 17.94 for  in situ  lesions and 26.24 for invasive cases. Average epidermal CD207+ cells count was 164.47 for all cases, 183.00 for  in situ  lesions and 150.78 – for invasive cases. In case of invasive melanomas, peritumoral CD207+ cells count was positively correlated with Breslow stage (R = 0.59) mitotic activity within the tumor (R = 0.62). Invasive cases with regression showed higher intratumoral and epidermal CD207+ cells count than the ones without (275.00 vs. 95.32 and 173.20 vs. 148.35) but lower peritumoral CD207+ cells count (17.60 vs. 27.26). Invasive cases with ulceration showed higher intratumoral and peritumoral CD207+ cells count than the ones without ulceration (220.08 vs. 55.67 and 44.17 vs. 9.69).   Conclusions : CD207+ cells play a role in both progression and regression of melanoma but their exact role needs further studies.",
author="Dyduch, Grzegorz
and Tyrak, Katarzyna E.
and Glajcar, Anna
and Szpor, Joanna
and Okoń, Krzysztof",
pages="233--239",
doi="10.5114/ada.2017.67845",
url="http://dx.doi.org/10.5114/ada.2017.67845"
}