@Article{Zegarska2017,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="34",
number="3",
year="2017",
title="Changes of Langerhans cells during skin ageing",
abstract=" Introduction : During the process of skin ageing, changes occur in all skin layers and all cells, including the Langerhans cells.   Aim:   To assess whether any quantitative difference in the number of CD1a+ LC cells/mm 2  and HLA-DR+ LC cells/mm 2  as well as in their morphological features can be observed during the course of different types of skin ageing.   Material and methods:   The study was conducted in a group of 60 women, which was divided into three independent groups: group I with symptoms of menopausal skin ageing, group II with symptoms of photoageing, group III with symptoms of chronological ageing. Skin biopsy samples were taken from the pre-auricular region from all of the participants. The number of CD1a+ LC cells/mm 2  and HLA-DR+ LC cells/mm 2  as well as their morphological features were evaluated.    Results : The frequency of CD1a+ LC and HLA-DR+ LC in all the studied groups was diverse. In groups I and III, the LC with large cell bodies and long, multi-branched processes were the majority. In group II, the LC had small cell bodies and their processes were mainly short and unbranched.   Conclusions : The obtained results indicate the presence of quantitative and morphological changes of the CD1a+ LC and HLA-DR+ LC during the course of different types of skin ageing.",
author="Zegarska, Barbara
and Pietkun, Katarzyna
and Giemza-Kucharska, Paulina
and Zegarski, Tomasz
and Nowacki, Maciej S.
and Romańska-Gocka, Krystyna",
pages="260--267",
doi="10.5114/ada.2017.67849",
url="http://dx.doi.org/10.5114/ada.2017.67849"
}