@Article{El-Sayed2017,
journal="Clinical and Experimental Hepatology",
issn="2392-1099",
volume="3",
number="3",
year="2017",
title="Elevated cystatin C: is it a reflection for kidney or liver impairment in hepatic children?",
abstract=" Aim of the study : To assess if elevated serum cystatin C (Cyst-C) is an indicator for renal or hepatic dysfunction in presence of liver fibrosis.    Material and methods : Data of 50 children with chronic liver diseases (CLDs), out of which 25 were without renal impairment, and 25 with renal impairment were analyzed. Twenty healthy children served as a healthy control group. Routine investigations, creatinine clearance, hepatitis viral markers, abdominal ultrasonography, and liver biopsy were performed for patients with CLDs. Measurement of serum Cyst-C concentration by particle induced immunonephelometry were completed for both patients and control group.    Results : Results showed that serum Cyst-C is not correlated with the degree of hepatic impairment (p > 0.05). Cyst-C levels were significantly higher in patients with renal impairment (3.66 ± 0.85) than those without   (0.71 ± 0.12), and healthy control group (0.63 ± 0.85). Cystatin-C showed significant elevation in patients with severe fibrosis with renal impairment (3.66 ± 0.85) than those without (0.76 ± 0.04) (p   2.34 mg/l predicting GFR   2.73 mg/l predicting GFR < 20 ml/min with accuracy of 81.5%.    Conclusions : Serum Cyst-C is a promising marker to estimate renal impairment in children with CLDs. Further studies are needed to estimate the accuracy of serum Cyst-C for early detection of renal impairment and close monitoring of the hepatic children.",
author="El-Sayed, Behairy
and El-Araby, Hanaa
and Adawy, Nermin
and Hassona, Mona
and El-Nady, Naglaa
and Zakaria, Haidy
and Khedr, Mohammed",
pages="159--163",
doi="10.5114/ceh.2017.68399",
url="http://dx.doi.org/10.5114/ceh.2017.68399"
}