@Article{Anand2017,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="21",
number="2",
year="2017",
title="Expression of vitamin D receptor and vitamin D status in patients with oral neoplasms and effect of vitamin D supplementation on quality of life in advanced cancer treatment",
abstract=" Aim of the study:  Vitamin D receptor (VDR) expression and serum vitamin D scores in oral premalignant lesions and oral cancer have not been widely analyzed. The role of vitamin D supplementation in advanced oral cancer for improving quality of life (QOL) is also a matter of research.   Material and methods:    Vitamin D receptor expression and vitamin D scores were analyzed in normal oral mucosa (n = 95), leukoplakia (n = 23) and oral cancer (n = 87). 45 patients with advanced oral cancer subjected to chemoradiation were evaluated for the effect of vitamin D supplementation on most observable QOL parameters such as oral mucositis, swallowing performance and overall QOL.   Results:   Vitamin D receptor expression was increased in oral neoplastic lesions. Vitamin D scores were significantly lower in cases compared to healthy controls (p = 0.002). Vitamin D supplementation significantly reduced the therapy-related toxicities in advanced cancer, thus reducing morbidity and improving QOL.    Conclusions :  Vitamin D receptor expression is increased in premalignant lesions and oral cancer. Vitamin D insufficiency and deficiency are prevalent in patients with oral neoplastic lesions. Vitamin D supplementation has a role in reducing treatment-related toxicities, especially in advanced cancer.",
author="Anand, Akshay
and Singh, Suyash
and Sonkar, Abhinav A.
and Husain, Nuzhat
and Singh, Kul Ranjan
and Singh, Sudhir
and Kushwaha, Jitendra K.",
pages="145--151",
doi="10.5114/wo.2017.68623",
url="http://dx.doi.org/10.5114/wo.2017.68623"
}