@Article{Urbanowicz2017,
journal="Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery",
issn="1731-5530",
volume="14",
number="2",
year="2017",
title="The incidence of aspirin resistance in heart transplantation recipients",
abstract=" Introduction : Coronary allograft vasculopathy can cause as many deaths as infections or rejection episodes within 3 years following heart transplantation.    Aim:   To compare the aspirin resistance rate in an allograft heart transplantation population and in a control group by laboratory tests including the Aspirin-Resistant Patients Identification Test (ASPItest).   Material and methods:  A total of 24 heart recipients (20 men and 4 women) at a mean age of 48 ±13 years who underwent routine clinical follow-up were consecutively enrolled in group 1.The control group consisted of 24 patients (19 men and 5 wo­men) at a mean age of 64 ±7 years waiting for coronary artery bypass grafting in our department. All patients were treated with a standard dose of 75 mg aspirin (ASA) daily.   Results : Aspirin resistance was evaluated by the Multiplate platelet function test. The ASPItest revealed a mean value of 27 ±22 U in the transplant group. Results above 30 U were obtained in 8 (34%) patients, with a mean value of 50.3 ±20.6 U, indicating aspirin resistance. In the control group ASPItest results above 30 U were obtained in 5 (20%) patients, with a mean value of 43.3 ±6.4 U.   Conclusions : There is a high incidence (34% vs. 20%, NS) of ASA resistance in heart transplantation recipients and in the general population, respectively.",
author="Urbanowicz, Tomasz
and Komosa, Anna
and Michalak, Michał
and Mularek, Tatiana
and Cassadei, Veronica
and Grajek, Stefan
and Jemielity, Marek",
pages="115--119",
doi="10.5114/kitp.2017.68742",
url="http://dx.doi.org/10.5114/kitp.2017.68742"
}