@Article{Cemil2017,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="34",
number="4",
year="2017",
title="Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?",
abstract="  Introduction:   Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis.     Aim:   To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP.     Material and methods:   Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group.     Results:   The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients.    Conclusions:   Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.",
author="Cemil, Bengu Cevirgen
and Yilmazer, Demet
and Atas, Hatice
and Cengiz, Fatma Pelin
and Canpolat, Filiz
and Alper, Murat
and Gonul, Muzeyyen",
pages="322--327",
doi="10.5114/ada.2017.69311",
url="http://dx.doi.org/10.5114/ada.2017.69311"
}