@Article{Erpolat2017,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="34",
number="4",
year="2017",
title="Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism",
abstract="  Introduction:  Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear.     Aim:    To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism.    Material and methods:    Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit. The serum C-reactive protein concentration and eosinophil counts in peripheral blood were evaluated.    Results:   The BDNF serum levels were detectable in both SD patients and healthy controls. The BDNF serum levels were significantly higher in patients with SD compared with healthy controls (p = 0.004). There was a positive but weak correlation between serum BDNF and CRP levels; it was not statistically significant (r = 0.211, p = 0.255). There was also a positive but weak correlation between serum BDNF and eosinophil counts; it was not statistically significant (r = 0.271, p = 0.141).    Conclusions:    The present study shows that BDNF is increased in the serum levels of patients with SD, suggesting a role for BDNF in the pathophysiology of this disorder.",
author="Erpolat, Seval
and Celik, Huseyin Tugrul
and Bozkurt, Bulent",
pages="346--349",
doi="10.5114/ada.2017.69315",
url="http://dx.doi.org/10.5114/ada.2017.69315"
}