@Article{Woźniak2017,
journal="Advances in Psychiatry and Neurology/Postępy Psychiatrii i Neurologii",
issn="1230-2813",
volume="26",
number="2",
year="2017",
title="Reduction in the volume of the front part of the hippocampus in schizophrenics with hyponatremia on hospital admission",
abstract=" Purpose:   Evaluation of  the  volume of  the  front part of  hippocampi in schizophrenics with hyponatremia on psychiatric ward admission.   Methods:  Hippocampal volumes were compared across a  group of  11 schizophrenics with hyponatremia and 22 patients with normonatremia, in the  whole groups and in 11 couples matched in terms of  gender, age and the  disease duration. The  groups were characterised in terms of  demographic (gender, age) and clinical (course of  illness, pharmacotherapy, tobacco smoking) features. All the  participants were right-handed. The  hippocampal volumes were manually measured on the  basis of  the  magnetic resonance imaging (MRI), using manual contouring, separately and jointly for the  right and left hippocampus, then the  obtained results were standardised for the  maximum transverse brain diameter (MTBD), the  maximum trans-pineal inner table diameter (LTID) or the  height.   Results : No relation was found between hyponatremia and the  MTBD. In patients with hyponatremia, a  smaller volume of  the  left hippocampus was observed, both using direct measurement and after standardisation for the  MTBD. The  analysis of  regression indicates a  relation model, in which the  reduction in the  left hippocampus is explained by the  covariance of  hyponatremia and MTBD values.   Conclusions : Dependency of  reduction in the  volume of  the  left hippocampus on hyponatremia observed in patients with schizophrenia encourages a  number of  pathogenic hypotheses whose interpretation, however, urges caution as the  phenomenon itself is complex, and methodological limitations of  the  undertaken research are present.",
author="Woźniak, Piotr Antoni
and Olędzka-Oręziak, Małgorzata
and Poniatowska, Renata
and Motyl, Rafał
and Wardyn, Kazimierz Andrzej",
pages="63--74",
doi="10.5114/ppn.2017.69375",
url="http://dx.doi.org/10.5114/ppn.2017.69375"
}