@Article{Olejek2005,
journal="Ginekologia Praktyczna  - - -       <span style=color: red>ARCHIVAL</span>",
issn="1231-6407",
year="2005",
title="TGF-beta1 cytokine and TGF-beta1 receptors I, II, III expression in lichen sclerosus of vulva",
abstract=" The aim of the study:  Evaluation of the expression of TGF-beta1 and its receptors in tissues with vulvar lichen sclerosus. Material and methods: 23 vulvar tissue samples (9 cases of lichen sclerosus, 14 \&#8211; normal tissues) obtained during diagnosis or surgery from patients hospitalised in Department of Obstetrics and Gynecology in Bytom. Vulvar tissue samples obtained during plastic surgery were used as a control group. All tissue samples had histopathological and molecular examination to the presence of TGF-beta 1 and its receptors I, II, III genes. Quantitative analysis was performed using QRT-PCR (Taq Man) technique.   Results:  Mean number of mRNA copies in lichen sclerosus was: for TGF-beta1 \&#8211; 11484.6, TGF R1 \&#8211; 26530.8, TGF R2 \&#8211; 27851.7 and TGF R3 \&#8211; 15373.6 in 1 mg of total RNA. The mean number of mRNA copies in 1 mg of total RNA in the control group was: TGF-beta1 \&#8211; 463.9, 1185.9 \&#8211; TGF R1, 3450.9 \&#8211; TGF R2 and 340.9 \&#8211; TGF R3.  Conclusions: 1. The pathological vulvar tissue is characterised with a bigger expression of TGF-beta1 and its receptors comparing to a health tissue. 2. The highest expression of TGFR1 and TGFR2 genes in vulvar lichen sclerosus suggesting enough cycle control of tissue by TGF-beta1. 3. The group of patients with vulvar lichen sclerosus needs control, becouse the vulvar pathology can be higher.",
author="Olejek, Anita
and Michalska, Agnieszka
and Mazurek, Urszula
and Kuśmierz, Dariusz
and Wilczok, Tadeusz",
pages="38--43",
url="https://www.termedia.pl/TGF-beta1-cytokine-and-TGF-beta1-receptors-I-II-III-expression-in-lichen-sclerosus-of-vulva,5,3055,1,1.html"
}