@Article{Perek2017,
journal="Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery",
issn="1731-5530",
volume="14",
number="3",
year="2017",
title="Late subclinical hemolysis and long-term outcomes after aortic valve replacement with On-X mechanical prostheses – a preliminary single-center report",
abstract=" Introduction : Aortic valve replacement (AVR) with a mechanical prosthesis is not free from late complications.    Aim : To evaluate the prevalence of subclinical hemolysis after AVR with On-X prostheses and assess its impact on long-term outcomes.    Material and methods : The prospective study included 84 consecutive patients aged 58.3 ±10.3 years who underwent AVR. They were retrospectively split into group H (n = 12; 14.3%) with prosthesis-related subclinical hemolysis and a control group (C; n = 72; 85.7%). All operations were performed via median sternotomy using cardio-pulmonary bypass. At the end of follow-up, echocardiography was carried out and blood samples for morphology and biochemistry (lactate dehydrogenase (LDH), bilirubin, haptoglobin) were taken.   Results : The rate of subclinical hemolysis in patients with properly working prostheses was 14.3% and it was the highest (33.3%) for the smallest valves. Although an improvement in functional status was noted in both groups, it was less evident in group H than in group C (p = 0.007). At the end of follow-up, 97.2% in group C and 75.0% in group H were found in NYHA classes I and II. Patients in group H had significantly lower hemoglobin, hematocrit, and haptoglobin and higher LDH activity than group C subjects. In group H, systolic gradients of On-X valves were higher whereas effective orifice area was smaller than in group C.   Conclusions : Our study proved that prosthesis-induced subclinical hemolysis is seen even after implantation of the latest generation mechanical prostheses, particularly of small diameter, and its degree may impact late outcome.",
author="Perek, Bartłomiej
and Sławek, Sylwia
and Malińska, Agnieszka
and Katyńska, Izabela
and Puślecki, Mateusz
and Szymak-Pawełczyk, Bogumiła
and Nowicki, Michał
and Jemielity, Marek",
pages="175--179",
doi="10.5114/kitp.2017.70531",
url="http://dx.doi.org/10.5114/kitp.2017.70531"
}