@Article{Namysłowski2018,
journal="Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii",
issn="1642-395X",
volume="35",
number="5",
year="2018",
title="The importance of specific IgE antibodies in epidemiology of allergic rhinitis and asthma – the Epidemiology of Allergic Diseases in Poland (ECAP) survey: part one. Influence of allergy risk factors on concentration of specific IgE antibodies in serum",
abstract=" Introduction:   Specific immunoglobulins E (sIgE) are important parameters to estimate severity of allergic diseases.   Aim : To determine the influence of allergy risk factors on the concentration of specific IgE antibodies in serum.   Material and methods : The concentration of sIgE antibodies against allergens  Dermatophagoides pteronyssinus , cat dander, timothy grass,  Alternaria alternata  were determined in serum of 4077 respondents randomly selected from 9 regions (ECAP study). The positive results of sIgE (≥ 0.35 IU/ml) were correlated to answers in questionnaires ECRHSII and ISAAC.   Results : sIgE are more frequently detected in respondents declaring an allergic disease of a father than of a mother ( D. pteronyssinus  p < 0.05,  A. alternata  p < 0.01). An early beginning to attend school, kindergarten or nursery increases the frequency of sIgE detection (p < 0.05). If the number of children who slept in the same room as a respondent before the respondent was five years old, was lower, sIgE antibodies are more frequently detected (p < 0.05). Relating to: 1) all 4 allergens, sIgE are the most frequently detected in respondents declaring absence of a carpet/rug at home (p < 0.05), 2) cat dander – less frequently detected in respondents who have a cat at home at the age of 1–4 years (p < 0.005).   Conclusions : Carpets/rugs capture a portion of mite, epidermal, mould allergens located at home, wherefore absence of a carpet or rug causes greater stimulation of an immune system by these allergens; as a consequence, IgE antibodies are the most frequently detected in respondents. Household contacts of the respondents, at the age of 1–4 years, with cats induced partial immune tolerance to cat dander.",
author="Namysłowski, Andrzej
and Samoliński, Bolesław K.
and Lipiec, Agnieszka
and Zieliński, Wojciech
and Sybilski, Adam J.
and Walkiewicz, Artur
and Samel-Kowalik, Piotr
and Samoliński, Krzysztof
and Raciborski, Filip",
pages="520--526",
doi="10.5114/pdia.2017.70894",
url="http://dx.doi.org/10.5114/pdia.2017.70894"
}