@Article{Jo2017,
journal="Polish Journal of Pathology",
issn="1233-9687",
volume="68",
number="3",
year="2017",
title="Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers",
abstract="Both  CUX1  and  SIRT1  are considered tumor suppressor genes (TSGs), but it is not known whether  CUX1  and  SIRT1  alterations are different between high microsatellite instability (MSI-H) and microsatellite stable MSI (MSS) cancers. We identified frameshift mutations of  CUX1  in 4 cases of colorectal cancer (CRC) and of  SIRT1  in 1 case of gastric cancer (GC) and 3 cases of CRC. All of them were found in GC or CRC with MSI-H (3.5% of MSI-H for each gene), but neither in GC nor CRC with MSS. In addition, we analyzed intratumoral heterogeneity (ITH) of the  CUX1  frameshift mutation and found that two CRCs (12.5%) harbored regional ITH of the frameshift mutation. Our data indicate that there exist frameshift mutations of  CUX1  and  SIRT1  genes as well as ITH of  CUX1  frameshift mutation in MSI-H cancers, which together might play a role in tumorigenesis of GC and CRC with MSI-H.",
author="Jo, Yun Sol
and Kim, Min Sung
and Yoo, Nam Jin
and Lee, Sug Hyung",
pages="258--260",
doi="10.5114/pjp.2017.71534",
url="http://dx.doi.org/10.5114/pjp.2017.71534"
}