@Article{Zielińska2016,
journal="Klinika Oczna / Acta Ophthalmologica Polonica",
issn="0023-2157",
volume="118",
number="4",
year="2016",
title="Effect of 0.1% diclofenac ophthalmic solution on inflammatory response and macular thickness following phacoemulsification cataract surgery",
abstract=" Purpose : To evaluate 0.1% diclofenac sodium as an adjunctive therapy with loteprednol etabonate on postoperative inflammation in the anterior chamber and on foveal and parafoveal retinal thickness.  	 Material and methods : Eighty eyes eligible for phacoemulsification were enrolled in a randomized clinical trial. Patients in group I (N = 40) received anti-inflammatory treatment consisting of 0.1% diclofenac with 0.5% loteprednol; group II (N = 40) patients received 0.5% loteprednol alone. Best corrected visual acuity and intraocular pressure were measured, and laser flarephotometry was done. Foveal and parafoveal thickness were assessed by optical coherence tomography.  	 Results : Median flare values decreased more rapidly in group I at 7 and 14 days (7.9 and 7.4 ph/ms, respectively) than in group II   (13.7 and 11.8 ph/ms, respectively; p < 0.0001). Group II had significantly increased parafoveal thickness at 14 and 42 days (median 285.59 μm, p = 0.001 and 288.38 μm, p < 0.001, respectively). Parafoveal thickness differed significantly between groups at 14 and 42 days (p = 0.0085, p = 0.0004, respectively).  	 Conclusions : Eyes treated with both diclofenac sodium and loteprednol etabonate showed less inflammatory response and were less likely to develop foveal and parafoveal thickening than those treated with steroid only.",
author="Zielińska, Edyta
and Rokicki, Dariusz
and Wielgórski, Mariusz
and Szaflik, Jerzy
and Szaflik, Jacek P.",
pages="270--277",
doi="10.5114/ko.2016.71738",
url="http://dx.doi.org/10.5114/ko.2016.71738"
}