@Article{Haghighat2017,
journal="Gastroenterology Review/Przegląd Gastroenterologiczny",
issn="1895-5770",
volume="12",
number="4",
year="2017",
title="The efficacy and duration of treatment with propranolol in children with cyclic vomiting syndrome in southern Iran",
abstract=" Introduction : Cyclic vomiting syndrome is a functional disorder characterised by repeated episodes of nausea and vomiting with symptom-free intervals between the attacks. Cyclic vomiting syndrome is a migraine equivalent; therefore, anti-migraine medications are effective for cyclic vomiting syndrome prophylaxis, but duration of treatment is not clear.    Aim : To determine the efficacy and duration of drug therapy in cyclic vomiting syndrome.    Material and methods : This study was conducted on 206 cases of cyclic vomiting syndrome, who were treated with propranolol as prophylaxis. After they were symptom-free for at least 9 months, propranolol was tapered and discontinued and then they were followed for at least 6 months after drug withdrawal for evaluation of recurrence.    Results : The study subjects included 127 boys and 79 girls. The mean age of symptom onset was 3.4 years (range: 3 months to 14.5 years) and the mean age at the time of diagnosis was 5.7 years (range: 8.4 months to 18 years). Among the 206 patients in whom propranolol was discontinued, only 16 (7.8%) subjects developed recurrence of symptoms in the 6-month follow-up period.    Conclusions : There is no need to continue prophylaxis of cyclic vomiting syndrome for a long time. It is also possible to make the duration of drug therapy shorter, which is useful for the convenience of the patients and prevention of drug side effects.",
author="Haghighat, Mahmoud
and Memari, Hajar
and Honar, Naser
and Dehghani, Seyed Mohsen
and Imanieh, Mohammad-Hadi
and Injoo, Seyed-Javad
and Javaherizadeh, Hazhir",
pages="291--295",
doi="10.5114/pg.2017.72105",
url="http://dx.doi.org/10.5114/pg.2017.72105"
}