@Article{Rutkowski2017,
journal="Contemporary Oncology/Współczesna Onkologia",
issn="1428-2526",
volume="21",
number="4",
year="2017",
title="The analysis of the long-term outcomes of sorafenib therapy in routine practice in imatinib and sunitinib resistant gastrointestinal stromal tumors (GIST)*",
abstract=" Aim of the study  was to analyze the outcome of treatment and factors predicting results of sorafenib therapy in inoperable/metastatic CD117-positive GIST patients after failure on imatinib and sunitinib.   Material and methods : We identified 60 consecutive patients (40 men, 20 women) with advanced inoperable/metastatic GIST after failure on at least imatinib and sunitinib treated in one sarcoma center with sorafenib at initial dose 2 × 400 mg daily in 2007–2015 (in 56 cases it was 3rd line therapy). Median follow-up time was 39 months.    Results : One year progression-free survival (PFS; calculated from the date of the start of sorafenib to disease progression) rate was 23% and median PFS = 7.7 months. The median overall survival (OS) was 13.5 months calculated from sorafenib start (1-year OS rate = 57%) and 7 years from imatinib start. Three patients (5%) had objective partial responses to therapy, 31 patients (52%) had stabilization of disease > 4 months. Primary tumor mutational status was known in 43 cases (73%), but we have not identified the differences in PFS between tumors carrying different KIT/PDGFRA mutations. The most common adverse events were: diarrhoea, hand and foot syndrome, fatigue, loss of weight and skin reactions; grade 3–5 toxicity occurred in 35% of patients. 23 patients required sorafenib dose reductions due to AEs.    Conclusions : We confirmed that many advanced GIST patients benefit from sorafenib therapy after imatinib/sunitinib failure with OS > 1 year.",
author="Rutkowski, Piotr
and Jagielska, Beata
and Andrzejuk, Jolanta
and Bylina, Elzbieta
and Lugowska, Iwona
and Switaj, Tomasz
and Kosela-Paterczyk, Hanna
and Kozak, Katarzyna
and Falkowski, Slawomir
and Klimczak, Anna",
pages="285--289",
doi="10.5114/wo.2017.72393",
url="http://dx.doi.org/10.5114/wo.2017.72393"
}